In 1309 pope Clement V transferred the papal residence from Rome to Avignon, France. In 1377, when pope Gregory XI moved the papal residence back to Rome, some noble families of Avignon left France to follow him. It was at that time, in Italy, that one of those families became known as Avignonesi - probably to simplify an otherwise difficult, foreign name. Soon the Avignonesi family separated into three branches which settled in Rome, Siena and Montepulciano.
It is not known exactly when Avignonesi's cellars were built, but they are doubtless among the most ancient in Italy. Palazzo Avignonesi was built according to a design by Jacopo Barozzi (called Vignola) in the second half of the XVI century and it has always been the cellars' seat.
In 1974 the Falvo brothers, owners of the vineyards in the municipality of Cortona, took over Avignonesi and refounded it investing greatly in viniculture, selecting the local varieties and introducing classical ones such as Chardonnay, Sauvignon Blanc, Cabernet Sauvignon, Merlot, Pinot Noir. Nowadays, Avignonesi consists of four wine-producing estates: Le Capezzine, I Poggetti, La Selva and La Lombarda. In total they comprise 218 hectares of open ground, 103 ha of vineyards and 7 ha of olive groves.